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Link between mind and body shows up in the link between pain and depression

November 6, 2008

When anticipating pain, the brains of subjects with major depressive disorder appear to react more strongly, and appear to display altered functioning of the neural network that moderates pain sensitivity, according to an article released on November 3, 2008 in Archives of General Psychiatry, one of the JAMA/Archives journals.

“Chronic pain and depression are common and often overlapping syndromes,” write the authors. More than 75% of patients with depression also manifest with recurring or chronic pain, while between 30 and 60% of patients with chronic pain report symptoms of depression. According to the authors, this association could have important implications if there is a biological mechanism that can be attributed. “Understanding the neurobiological basis of this relationship is important because the presence of comorbid pain contributes significantly to poorer outcomes and increased cost of treatment in major depressive disorder,” they say.

via Depression Patients Show Altered Response To Pain


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